Why do some people live to 100 in remarkably good health while others don’t? A study, published in Aging Cell, is taking a deep dive into this mystery by creating a biobank of centenarian stem cells—a resource that could reshape how we understand longevity.
Researchers from the New England Centenarian Study collected blood samples from individuals aged 100 and older, then used cutting-edge techniques to reprogram their cells into induced pluripotent stem cells (iPSCs). These iPSCs essentially rewind the biological clock, turning back into a youthful, flexible state that can develop into any cell type.
Why does this matter? Because these “super-aging” cells carry the genetic blueprint of people who have defied aging norms. Already, scientists have discovered that neurons derived from centenarian stem cells are better at resisting toxic proteins linked to Alzheimer’s. They’re also studying the surprising loss of the Y chromosome in some male donors—a potential clue in why women tend to outlive men.
This biobank isn’t just about studying aging—it could help develop new anti-aging treatments by identifying protective genetic factors. Since stem cells can be turned into heart, muscle, and immune cells, researchers now have a way to explore how different organs resist (or succumb to) aging.
As longevity science advances, one thing is clear: the key to a longer, healthier life may already be inside us—waiting to be unlocked.
