Extracellular vesicles derived from adipose stem cells (ASC-sEVs) have gained attention for their regenerative potential in skin health. A study examined whether combining ASC-sEVs with natural compounds could enhance their anti-aging effects. Using a systematic approach, researchers identified optimal formulations and evaluated their impact on skin cells exposed to UVB radiation.
Multi-omics analysis revealed that ASC-sEVs naturally contain bioactive molecules involved in collagen formation, pigmentation regulation, and oxidative stress response. To amplify these effects, researchers loaded ASC-sEVs with nicotinamide riboside, resveratrol, vitamin C, retinol, and arbutin. When tested in vitro, the combination treatments demonstrated greater efficacy than either ASC-sEVs or compounds alone.
Results showed that ASC-sEVs with specific compound combinations reduced reactive oxygen species by 22%, lowered melanin content by over 21%, and increased the expression of genes associated with collagen production. Importantly, no cytotoxic effects were observed, suggesting a safe and effective approach for enhancing skin regeneration.
This study highlights the potential of ASC-sEVs as delivery vehicles for bioactive compounds, offering a novel strategy for addressing skin aging.
