Ultraviolet (UV) radiation is a primary factor in skin aging, leading to decreased hydration, reduced collagen density, and impaired cellular regeneration. A study investigates the potential of a transfersomal serum (Trans) incorporating amniotic mesenchymal stem cell metabolite products (AMSC-MP) and hyaluronic acid (HA) to address these effects.
The serum utilizes transfersomes, which are composed of L-α-phosphatidylcholine and surfactants—either sodium cholate (SC) or stearylamine (SA). These formulations were developed with and without the addition of HA to assess its impact on particle size, skin absorption, and regenerative effects. The study found that the inclusion of HA increased the particle size of both Trans-SA and Trans-SC formulations but did not significantly alter the zeta potential. The relative deformability index, a measure of how well these vesicles can penetrate the skin, varied depending on the specific formulation.
In vivo experiments on UV-aged mice demonstrated that the serum containing HA led to increased skin hydration, higher collagen density, and a greater number of fibroblast cells, all of which are indicators of improved skin regeneration. Importantly, no erythema or adverse reactions were observed 24 hours after topical application, suggesting that the formulation is well tolerated.
These findings suggest that an AMSC-MP transfersomal serum with HA may be an effective approach for promoting skin regeneration in UV-damaged skin.
