Skin aging is characterized by structural degradation and reduced regenerative capacity, largely due to increased cellular senescence and apoptosis. While various therapeutic strategies have been explored, mesenchymal stem cells (MSCs) have shown potential in reversing age-related changes in skin tissue.
A study investigated the effects of MSC therapy on skin aging by intravenously administering MSCs to elderly rhesus monkeys. Over six months, researchers observed improvements in skin tissue structure, along with shifts in protein expression patterns associated with aging. Proteomic analysis identified histone acetyltransferase 1 (HAT1) as a key factor in these regenerative processes.
To further investigate HAT1’s role, researchers developed an in vitro model using aging human skin fibroblasts (HSFs) co-cultured with human umbilical cord-derived MSCs (hUCMSCs). Functional studies involving HAT1 knockdown and overexpression confirmed its involvement in skin aging reversal. The study suggests that MSCs contribute to skin repair by modulating molecular pathways, with HAT1 playing a central role.
These findings provide new insights into the biological mechanisms underlying MSC-based interventions for skin aging and highlight HAT1 as a potential therapeutic target.
