MSC-treated group showed significantly lower risk of mortality than the control group (p = 0.03). No statistical significance was observed on the incidence of AEs
New research from Boston Medical Center and Boston University Chobanian & Avedisian School of Medicine’s Center for Regenerative Medicine (CReM) found evidence that a novel stem cell treatment, using mRNA successfully used to produce the COVID-19 vaccines.
“The cells we transplant are early-stage neurons that are in the process of developing into dopamine cells, but that have not fully matured. After the cells are transplanted into the patient’s brain, we expect them to mature, send out long nerve fibres and start producing dopamine, as we have seen them do in our preclinical studies,” says Agnete Kirkeby.
Starting from the late 1980s, stem cell scientists attempted CRT using fVM tissues dissected from aborted embryos (typically 6 to 9 weeks old) because they showed the most promising outcomes among various dopamine-producing cells.
The researchers sampled gut tissue from 53 Crohn’s disease patients during routine colonoscopies at the Inflammatory Bowel Disease Center at UC San Diego Health. The patients came from diverse backgrounds and presented with a variety of clinical symptoms
Increasing evidence indicates a role for EBV in the pathogenesis of multiple sclerosis (MS). EBV-infected autoreactive B cells might accumulate in the CNS because of defective cytotoxic CD8+ T cell immunity. We sought to determine the feasibility and safety of treating progressive MS patients with autologous EBV-specific T cell therapy.
Because mitochondrial activity can better reflect cell vitality, cell viability was assessed using the ATP assay. A luciferase-based kit (Beyotime Biotechnology, Jiangsu, China) was used to measure the ATP level according to the manufacturer’s instructions.
Inflammatory bowel diseases (IBD) are chronic inflammatory conditions that affect the gastrointestinal tract, mainly encompassing Crohn’s disease (CD) and ulcerative colitis (UC)1. So far, the etiology of IBD has not been clearly identified, and it is generally believed to be caused by a disordered mucosal immune response to environmental factors in genetically susceptible hosts
Dynamic interactions between the gastrointestinal epithelium and the mucosal immune system result in intestinal homeostasis and optimal immunosurveillance, but a destabilization in these interactions among predisposed people can lead to development of chronic inflammatory diseases called inflammatory bowel disease (IBD), which mainly covers Crohn’s disease (CD) and ulcerative colitis (UC)
Developmentally early cells, including hematopoietic stem progenitor cells (HSPCs), mesenchymal stem cells (MSCs), endothelial progenitor cells (EPCs), and very small embryonic-like stem cells (VSELs), are mobilized into peripheral blood (PB) in response to tissue/organ injury. We sought to determine whether these cells are mobilized into PB in patients with Crohn’s disease (CD).
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