Arthritis, COPD, Diabetes Frailty syndrome, Localized Ischemia, Multiple Sclerosis, Pulmonary Fibrosis, Rheumatoid Arthritis, Vasular insufficiency, Alzheimer’s disease, Critical Limb Ischemia, Erectile Dysfunction, Liver failure, Lupus, Parkinson’s Disease, Renal Failure, Stroke, Heart Failure.