Burn injuries remain a significant global health concern, and stem cell-based treatments offer potential avenues for improving wound repair. A bibliometric analysis examined 1,648 studies published between 1978 and 2022, mapping the development of stem cell research in burn healing.
The study identifies epidermal stem cells (ESCs) and mesenchymal stem cells (MSCs) as focal points of research. ESCs contribute to epidermal regeneration, while MSCs and their derived exosomes are noted for their ability to modulate inflammation and promote tissue repair through paracrine signaling.
The analysis further highlights the United States as the leading contributor in this area, with institutions such as LV Prasad Eye Institute, Burns, and researchers like Scheffer C.G. Tseng playing a significant role in advancing the field.
By examining citation networks and keyword trends, the study pinpoints mechanistic studies of ESCs and MSC-based therapies as primary research hotspots. The findings highlight growing clinical interest in how these stem cells interact with damaged tissue and influence wound healing at a molecular level.
These mechanisms may contribute to refining stem cell-based therapies for burn treatment. These therapies may also have applications in tissue engineering and regenerative medicine.
